Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry

Chem Commun (Camb). 2014 Nov 7;50(86):13157-60. doi: 10.1039/c4cc05909c.

Abstract

A single maleimide was installed onto the self-assembled monolayer of gold nanoparticles by copper-free click chemistry. Simple covalent biofunctionalisation is demonstrated by coupling fibroblast growth factor 2 and an oligosaccharide in a 1 : 1 stoichiometry by thiol-Michael addition.

MeSH terms

  • Click Chemistry
  • Copper / chemistry
  • Fibroblast Growth Factor 2 / chemistry
  • Fibroblast Growth Factor 2 / metabolism
  • Gold / chemistry*
  • Maleimides / chemistry*
  • Metal Nanoparticles / chemistry*
  • Oligosaccharides / chemistry
  • Oligosaccharides / metabolism
  • Sulfhydryl Compounds / chemistry

Substances

  • Maleimides
  • Oligosaccharides
  • Sulfhydryl Compounds
  • Fibroblast Growth Factor 2
  • maleimide
  • Gold
  • Copper