Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population

Qingyi Wei; Dianke Yu; Mingbo Liu; Mengyun Wang; Miaoqing Zhao; Ming Liu; Weihua Jia; Hongxia Ma; Jugao Fang; Wei Xu; Kexing Chen; Zhengang Xu; Jialing Wang; Linli Tian; Hua Yuan; Jiang Chang; Zhibin Hu; Lixun Wei; Ying Huang; Yaling Han; Jie Liu; Demin Han; Hongbing Shen; Shiming Yang; Hong Zheng; Qinghai Ji; Duanshu Li; Wen Tan; Chen Wu; Dongxin Lin

doi:10.1038/ng.3090

Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population

Nat Genet. 2014 Oct;46(10):1110-4. doi: 10.1038/ng.3090. Epub 2014 Sep 7.

Authors

Qingyi Wei¹, Dianke Yu², Mingbo Liu³, Mengyun Wang⁴, Miaoqing Zhao⁵, Ming Liu⁶, Weihua Jia⁷, Hongxia Ma⁸, Jugao Fang⁹, Wei Xu¹⁰, Kexing Chen¹¹, Zhengang Xu¹², Jialing Wang¹³, Linli Tian⁶, Hua Yuan⁸, Jiang Chang¹⁴, Zhibin Hu⁸, Lixun Wei¹⁴, Ying Huang¹⁴, Yaling Han¹⁴, Jie Liu¹², Demin Han⁹, Hongbing Shen⁸, Shiming Yang¹³, Hong Zheng¹¹, Qinghai Ji¹⁵, Duanshu Li¹⁵, Wen Tan¹⁴, Chen Wu¹⁴, Dongxin Lin¹⁴

Affiliations

¹ 1] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. [3] Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [4] [5].
² 1] State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [2].
³ 1] Department of Otolaryngology-Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing, China. [2].
⁴ 1] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. [2] Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [3].
⁵ Department of Pathology, Provincial Hospital affiliated to Shandong University, Jinan, China.
⁶ Department of Otorhinolaryngology and Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
⁷ State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China.
⁸ Department of Epidemiology and Biostatistics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, China.
⁹ Department of Otolaryngology-Head and Neck Surgery, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing, China.
¹⁰ Department of Otolaryngology-Head and Neck Surgery, Provincial Hospital affiliated to Shandong University, Jinan, China.
¹¹ Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
¹² Department of Head and Neck Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹³ Department of Otolaryngology-Head and Neck Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
¹⁴ State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁵ Department of Head and Neck Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.

PMID: 25194280
DOI: 10.1038/ng.3090

Abstract

To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 × 10(-5)) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595) and 12q24 (rs10492336). The minor alleles of each of these loci showed protective effects, with odds ratios (95% confidence intervals) of 0.73 (0.68-0.78; P = 1.00 × 10(-20)), 0.78 (0.72-0.84; P = 2.43 × 10(-15)) and 0.71 (0.65-0.77; P = 4.48 × 10(-14)), respectively. None of these variants showed an interaction with smoking or drinking. This is the first GWAS to our knowledge solely on LSCC, and the findings might advance understanding of the etiology of LSCC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Asian People / genetics
Carcinoma, Squamous Cell / ethnology
Carcinoma, Squamous Cell / genetics*
China
Chromosomes, Human, Pair 11 / genetics
Chromosomes, Human, Pair 12 / genetics
Chromosomes, Human, Pair 6 / genetics
Esophageal Neoplasms / ethnology
Esophageal Neoplasms / genetics*
Female
Gene Frequency
Genetic Loci / genetics*
Genetic Predisposition to Disease / etiology
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study*
Genotype
Humans
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide