Chronic graft versus host disease and nephrotic syndrome

Saudi J Kidney Dis Transpl. 2014 Sep;25(5):1062-4. doi: 10.4103/1319-2442.139941.

Abstract

Disturbed kidney function is a common complication after bone marrow transplantation. Recently, attention has been given to immune-mediated glomerular damage related to graft versus host disease (GVHD). We describe a 19-year-old woman who developed membranous glomerulonephritis after bone marrow transplantation (BMT). Six months later, she developed soft palate, skin and liver lesions considered to be chronic GVHD. Fifteen months after undergoing BMT, this patient presented with nephrotic syndrome. A renal biopsy showed membranous glomerulonephritis associated with a focal segmental glomerulosclerosis. She was started on corticosteroid treatment with good outcome.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Biopsy
  • Bone Marrow Transplantation / adverse effects*
  • Female
  • Glomerulonephritis, Membranous / diagnosis
  • Glomerulonephritis, Membranous / drug therapy
  • Glomerulonephritis, Membranous / etiology*
  • Glomerulosclerosis, Focal Segmental / diagnosis
  • Glomerulosclerosis, Focal Segmental / drug therapy
  • Glomerulosclerosis, Focal Segmental / etiology*
  • Graft vs Host Disease / diagnosis
  • Graft vs Host Disease / drug therapy
  • Graft vs Host Disease / etiology*
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / surgery*
  • Nephrotic Syndrome / diagnosis
  • Nephrotic Syndrome / drug therapy
  • Nephrotic Syndrome / etiology*
  • Time Factors
  • Treatment Outcome
  • Young Adult

Substances

  • Adrenal Cortex Hormones