microRNAs in hematopoiesis

Seka S Lazare; Edyta E Wojtowicz; Leonid V Bystrykh; Gerald de Haan

doi:10.1016/j.yexcr.2014.08.033

microRNAs in hematopoiesis

Exp Cell Res. 2014 Dec 10;329(2):234-8. doi: 10.1016/j.yexcr.2014.08.033. Epub 2014 Sep 3.

Authors

Seka S Lazare¹, Edyta E Wojtowicz², Leonid V Bystrykh², Gerald de Haan²

Affiliations

¹ Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands. Electronic address: s.s.lazare@umcg.nl.
² Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.

PMID: 25192911
DOI: 10.1016/j.yexcr.2014.08.033

Abstract

miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors. In this review, we highlight miRNAs shown to be important for HSC maintenance and lineage differentiation with focus on their interaction with transcription factors. We also pay attention to the diverse modes of miRNA regulation.

Keywords: Hematopoiesis; Lineage commitment; Transcription factors; microRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / genetics*
Cell Lineage / genetics*
Hematopoiesis / physiology*
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / physiology*
Humans
MicroRNAs / genetics*

Substances

MicroRNAs