Shaping dendritic spines in autism spectrum disorder: mTORC1-dependent macroautophagy

Neuron. 2014 Sep 3;83(5):994-6. doi: 10.1016/j.neuron.2014.08.021.

Abstract

In this issue of Neuron, Tang et al. (2014) explore the relationship between developmental dendritic pruning, elevated mTORC1 signaling, macroautophagy, and autism spectrum disorder. The study provides valuable new insight into mTORC1-dependent cellular dysfunction and neurodevelopmental disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Autistic Disorder / pathology*
  • Autophagy / physiology*
  • Dendritic Spines / genetics*
  • Female
  • Humans
  • Male
  • Neurons / pathology*
  • Synapses / pathology*
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • MTOR protein, human
  • TOR Serine-Threonine Kinases