Abstract
The ER stress-inducible transcription factor, x-box binding protein 1 (XBP1), which enhances protein glycosylation in the endoplasmic reticulum (ER), was shown to also enhance protein glycosylation outside the ER, via a process called O-GlcNAcylation, which protected the heart from ischemia/reperfusion damage.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Animals
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Biosynthetic Pathways*
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DNA-Binding Proteins / metabolism*
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Hexosamines / metabolism*
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Humans
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Male
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Transcription Factors / metabolism*
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Unfolded Protein Response*
Substances
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DNA-Binding Proteins
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Hexosamines
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Transcription Factors