Genetics of obsessive-compulsive disorder and related disorders

Heidi A Browne; Shannon L Gair; Jeremiah M Scharf; Dorothy E Grice

doi:10.1016/j.psc.2014.06.002

Genetics of obsessive-compulsive disorder and related disorders

Psychiatr Clin North Am. 2014 Sep;37(3):319-35. doi: 10.1016/j.psc.2014.06.002. Epub 2014 Jul 23.

Authors

Heidi A Browne¹, Shannon L Gair², Jeremiah M Scharf³, Dorothy E Grice⁴

Affiliations

¹ OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
² OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA.
³ Movement Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, 6254, Boston, MA 02114, USA; Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, 6254, Boston, MA 02114, USA. Electronic address: jscharf@partners.org.
⁴ OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: dorothy.grice@mssm.edu.

Abstract

Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

Keywords: Candidate gene; Familial recurrence; GWAS; Genetics; Heritability; Model system; OCD; Twin study.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Body Dysmorphic Disorders / genetics*
Chronic Disease
Disease Models, Animal
Diseases in Twins / genetics
Family Health
Genetic Association Studies / methods
Humans
Obsessive-Compulsive Disorder / genetics*
Recurrence
Tic Disorders / genetics*
Tourette Syndrome / genetics*
Trichotillomania / genetics*

Abstract

Publication types

MeSH terms

Grants and funding