Unconventional intraepithelial gut T cells: the TCR says it all

Nadia Kurd; Ellen A Robey

doi:10.1016/j.immuni.2014.08.004

Unconventional intraepithelial gut T cells: the TCR says it all

Immunity. 2014 Aug 21;41(2):167-8. doi: 10.1016/j.immuni.2014.08.004.

Authors

Nadia Kurd¹, Ellen A Robey²

Affiliations

¹ Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
² Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. Electronic address: erobey@berkeley.edu.

PMID: 25148016
DOI: 10.1016/j.immuni.2014.08.004

Abstract

The intestinal epithelium harbors a large number of T cells, including TCRαβ cells that lack expression of CD4 and CD8αβ coreceptors. In this issue of Immunity, Mayans et al. (2014) and McDonald et al. (2014) shed light on the specificity and development of this enigmatic T cell population.

Publication types

Comment

MeSH terms

Animals
CD4-Positive T-Lymphocytes / cytology*
CD4-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / cytology*
CD8-Positive T-Lymphocytes / immunology*
Cell Differentiation / immunology*
Cell Lineage / immunology*
Receptors, Antigen, T-Cell, alpha-beta / genetics*
Receptors, Antigen, T-Cell, alpha-beta / immunology*

Substances

Receptors, Antigen, T-Cell, alpha-beta