Peeking into a cool future: genome editing to delete PCSK9 and control hypercholesterolemia in a single shot

Circ Res. 2014 Aug 15;115(5):472-4. doi: 10.1161/CIRCRESAHA.114.304575.
No abstract available

Keywords: Editorials; PCSK9 protein, human; cholesterol; genetic therapy; lipoproteins.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Clustered Regularly Interspaced Short Palindromic Repeats*
  • Female
  • Liver / enzymology*
  • Male
  • Mutation*
  • Proprotein Convertase 9
  • Proprotein Convertases / genetics*
  • RNA Editing*
  • RNA, Guide, CRISPR-Cas Systems
  • Serine Endopeptidases / genetics*

Substances

  • Pcsk9 protein, mouse
  • Proprotein Convertase 9
  • Proprotein Convertases
  • Serine Endopeptidases