Corticosteroid use is associated with a reduced incidence of Clostridium difficile-associated diarrhea: a retrospective cohort study

Anaerobe. 2014 Dec:30:27-9. doi: 10.1016/j.anaerobe.2014.07.010. Epub 2014 Aug 7.

Abstract

The impact of corticosteroid use on the incidence of Clostridium difficile-associated diarrhea (CDAD) was examined retrospectively in 532 patients receiving antibiotic treatment for respiratory infections. As determined by logistic regression, corticosteroids were associated with a decreased incidence of CDAD (Odds Ratio 0.12, 95% Confidence Interval 0.006-0.95).

Keywords: Clostridium difficile; Enterocolitis; Glucocorticoids; Prevention & control; Pseudomembranous.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Aged
  • Aged, 80 and over
  • Clostridioides difficile / isolation & purification*
  • Clostridium Infections / epidemiology*
  • Clostridium Infections / prevention & control
  • Cohort Studies
  • Diarrhea / epidemiology*
  • Diarrhea / prevention & control
  • Female
  • Humans
  • Incidence
  • Male
  • Retrospective Studies

Substances

  • Adrenal Cortex Hormones