RhoA mutations identified in diffuse gastric cancer

Jin Zhou; Yoku Hayakawa; Timothy C Wang; Adam J Bass

doi:10.1016/j.ccr.2014.06.022

RhoA mutations identified in diffuse gastric cancer

Cancer Cell. 2014 Jul 14;26(1):9-11. doi: 10.1016/j.ccr.2014.06.022.

Authors

Jin Zhou¹, Yoku Hayakawa², Timothy C Wang³, Adam J Bass⁴

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
² Division of Digestive and Liver Diseases and Herbert Irving Cancer Research Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
³ Division of Digestive and Liver Diseases and Herbert Irving Cancer Research Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: tcw21@columbia.edu.
⁴ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: adam_bass@dfci.harvard.edu.

Abstract

The diffuse-type histologic variant of gastric cancer is characterized by highly invasive growth patterns and lack of cellular cohesion. Two recent studies have identified highly recurrent mutations of the gene encoding the small GTPase RhoA and suggest that RhoA activity may have a tumor suppressive role in this disease.

MeSH terms

Anoikis
Cell Differentiation
Genetic Predisposition to Disease
Humans
Mutation*
Neoplasm Invasiveness
Phenotype
Prognosis
Risk Factors
Stomach Neoplasms / enzymology*
Stomach Neoplasms / genetics*
Stomach Neoplasms / pathology
rhoA GTP-Binding Protein / genetics*
rhoA GTP-Binding Protein / metabolism

Substances

RHOA protein, human
rhoA GTP-Binding Protein

Grants and funding

R01 CA093405/CA/NCI NIH HHS/United States