Ultrasensitive aptamer-based SERS detection of PSAs by heterogeneous satellite nanoassemblies

Wei Ma; Honghong Yin; Liguang Xu; Xiaoling Wu; Hua Kuang; Libing Wang; Chuanlai Xu

doi:10.1039/c4cc03734k

Ultrasensitive aptamer-based SERS detection of PSAs by heterogeneous satellite nanoassemblies

Chem Commun (Camb). 2014 Sep 4;50(68):9737-40. doi: 10.1039/c4cc03734k.

Authors

Wei Ma¹, Honghong Yin, Liguang Xu, Xiaoling Wu, Hua Kuang, Libing Wang, Chuanlai Xu

Affiliation

¹ State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, P. R. China. khecho@163.com.

PMID: 25020000
DOI: 10.1039/c4cc03734k

Abstract

An ultrasensitive method for surface enhanced Raman scattering (SERS) detection of prostate-specific antigens (PSAs) was established based on the aptamer directed core-satellite nanostructures. A limit of detection (LOD) of 4.8 aM for PSA was obtained.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Aptamers, Nucleotide / chemistry*
Base Sequence
Gold / chemistry
Humans
Limit of Detection
Male
Nanostructures / chemistry
Prostate-Specific Antigen / blood*
Spectrum Analysis, Raman / methods*

Substances

Aptamers, Nucleotide
Gold
Prostate-Specific Antigen