Mitobolites: the elixir of life

Cell Metab. 2014 Jul 1;20(1):8-9. doi: 10.1016/j.cmet.2014.06.013.

Abstract

One of the biggest challenges in biology is to understand how mitochondria influence aging and age-related diseases. Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / drug effects*
  • Humans
  • Ketoglutaric Acids / pharmacology*
  • Longevity / physiology*
  • Mitochondrial Proton-Translocating ATPases / metabolism*
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • Ketoglutaric Acids
  • TOR Serine-Threonine Kinases
  • Mitochondrial Proton-Translocating ATPases