Identification of EGF as an important regulator for promoting CYP3A4 expression in human embryonic stem cell-derived hepatocytes using TALEN-based gene targeting

J Genet Genomics. 2014 Jun 20;41(6):349-52. doi: 10.1016/j.jgg.2014.03.008. Epub 2014 Apr 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation
  • Cytochrome P-450 CYP3A / genetics*
  • Cytochrome P-450 CYP3A / metabolism
  • DNA Restriction Enzymes / metabolism*
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism*
  • Epidermal Growth Factor / metabolism*
  • Gene Knock-In Techniques / methods
  • Gene Targeting
  • Green Fluorescent Proteins / genetics
  • Hepatocytes / cytology
  • Hepatocytes / metabolism*
  • Humans

Substances

  • enhanced green fluorescent protein
  • Green Fluorescent Proteins
  • Epidermal Growth Factor
  • Cytochrome P-450 CYP3A
  • DNA Restriction Enzymes