Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma--a matched pair analysis from the German Hodgkin Study Group (GHSG)

Sylvia Hartmann; Dennis A Eichenauer; Annette Plütschow; Anja Mottok; Roshanak Bob; Karoline Koch; Heinz-Wolfram Bernd; Sergio Cogliatti; Michael Hummel; Alfred C Feller; German Ott; Peter Möller; Andreas Rosenwald; Harald Stein; Martin-Leo Hansmann; Andreas Engert; Wolfram Klapper

doi:10.1111/bjh.12997

Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma--a matched pair analysis from the German Hodgkin Study Group (GHSG)

Br J Haematol. 2014 Oct;167(2):238-42. doi: 10.1111/bjh.12997. Epub 2014 Jun 26.

Authors

Sylvia Hartmann¹, Dennis A Eichenauer, Annette Plütschow, Anja Mottok, Roshanak Bob, Karoline Koch, Heinz-Wolfram Bernd, Sergio Cogliatti, Michael Hummel, Alfred C Feller, German Ott, Peter Möller, Andreas Rosenwald, Harald Stein, Martin-Leo Hansmann, Andreas Engert, Wolfram Klapper

Affiliation

¹ Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.

PMID: 24965443
DOI: 10.1111/bjh.12997

Abstract

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity. We performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD15, IgD, phosphorylated STAT6, ICOS and Epstein-Barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non-significant trend towards a lower relapse rate, justifying further evaluation of this marker.

Keywords: histopathological feature; nodular lymphocyte-predominant Hodgkin lymphoma; prognostic impact.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Biomarkers, Tumor / analysis
Female
Fucosyltransferases / analysis
Herpesvirus 4, Human / isolation & purification
Hodgkin Disease / immunology
Hodgkin Disease / metabolism
Hodgkin Disease / pathology*
Hodgkin Disease / virology
Humans
Immunoglobulin D / analysis
Inducible T-Cell Co-Stimulator Protein / analysis
Lewis X Antigen / analysis
Lymphocyte Activation / immunology
Male
Matched-Pair Analysis
Middle Aged
Neoplasm Proteins / analysis
Neoplasm Staging
Prognosis
Recurrence
STAT6 Transcription Factor / analysis
T-Lymphocyte Subsets / immunology
Tumor Microenvironment / immunology
Young Adult

Substances

Biomarkers, Tumor
ICOS protein, human
Immunoglobulin D
Inducible T-Cell Co-Stimulator Protein
Lewis X Antigen
Neoplasm Proteins
STAT6 Transcription Factor
STAT6 protein, human
FUT4 protein, human
Fucosyltransferases