Interest of cytogenetic and FISH evaluation for prognosis evaluation in 198 patients with acute myeloid leukemia in first complete remission in a single institution

Leuk Res. 2014 Aug;38(8):907-12. doi: 10.1016/j.leukres.2014.05.021. Epub 2014 Jun 4.

Abstract

The prognostic interest of cytogenetic remission and fluorescent in situ hybridization (FISH) evaluation in patients with abnormal karyotype acute myeloid leukemia (AML) has been poorly studied. Among 198 patients that reached complete remission (CR), 24 did not reach cytogenetic remission (CyCR). CyCR had no prognosis impact, especially in patients with intermediate or unfavorable cytogenetic. Twenty of 52 evaluated patients in CyCR did not reach FISH CR. FISH CR was associated with better OS (p=0.004) and tended to be associated with better disease-free survival (DFS) (p=0.08). FISH evaluation may be a useful tool for prognosis evaluation and minimal residual disease (MRD) assessment in patients with abnormal cytogenetic AML.

Keywords: AML; Cytogenetic remission; FISH; Prognosis.

Publication types

  • Evaluation Study

MeSH terms

  • Abnormal Karyotype
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cytogenetic Analysis / methods*
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myeloid, Acute / diagnosis*
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / therapy*
  • Male
  • Middle Aged
  • Neoplasm, Residual
  • Predictive Value of Tests
  • Prognosis
  • Remission Induction
  • Young Adult