Poly(ADP-ribose): an organizer of cellular architecture

Anthony K L Leung

doi:10.1083/jcb.201402114

Poly(ADP-ribose): an organizer of cellular architecture

J Cell Biol. 2014 Jun 9;205(5):613-9. doi: 10.1083/jcb.201402114.

Author

Anthony K L Leung¹

Affiliation

¹ Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 anleung@jhsph.edu.

Abstract

Distinct properties of poly(ADP-ribose)-including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature-could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structures, such as DNA repair foci, spindle poles, and RNA granules. Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADP-ribose) could direct cellular organization.

MeSH terms

Animals
Cell Nucleolus / metabolism
DNA Damage
DNA Repair
Drosophila
Humans
Mitosis
Poly Adenosine Diphosphate Ribose / physiology*
Poly(ADP-ribose) Polymerases / metabolism
Protein Binding
Spindle Apparatus

Substances

Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases