RAREMETAL: fast and powerful meta-analysis for rare variants

Bioinformatics. 2014 Oct;30(19):2828-9. doi: 10.1093/bioinformatics/btu367. Epub 2014 Jun 3.

Abstract

Summary: RAREMETAL is a computationally efficient tool for meta-analysis of rare variants genotyped using sequencing or arrays. RAREMETAL facilitates analyses of individual studies, accommodates a variety of input file formats, handles related and unrelated individuals, executes both single variant and burden tests and performs conditional association analyses.

Availability and implementation: http://genome.sph.umich.edu/wiki/RAREMETAL for executables, source code, documentation and tutorial.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Computational Biology / methods*
  • Data Interpretation, Statistical
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Models, Statistical
  • Programming Languages
  • Quantitative Trait Loci
  • Reproducibility of Results
  • Software*