The Women's Healthy Heart Initiative clinic was launched in 2009 at the McGill University Health Centre to provide women with comprehensive primary prevention care. The mission of this nurse-led clinic is to increase awareness among women of their risk of heart disease and to empower them to be proactive in achieving heart health. In this article, the author discusses the findings from an analysis of clinical measures in the clinic's first three years of operation. The clinic has helped patients reduce their blood pressure, cholesterol levels and weight. The clinic's nurses have gained insights into the importance of self-referral and family history in preventive care. The results demonstrate the effectiveness of this collaborative care model in heart disease prevention.