Spontaneous biomimetic formation of (±)-dictazole B under irradiation with artificial sunlight

Angew Chem Int Ed Engl. 2014 Jun 16;53(25):6419-24. doi: 10.1002/anie.201403454. Epub 2014 May 9.

Abstract

Guided by biosynthetic considerations, the total synthesis of dictazole B is reported for the first time. Experimental evidence for an easy access to challenging cyclobutane alkaloids of marine origin, which are often postulated to be biosynthetic precursors of more complex structures, is provided.

Keywords: alkaloids; aplysinopsin; biomimetic synthesis; natural products; self-assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetics*
  • Cyclobutanes / chemical synthesis*
  • Cyclobutanes / chemistry
  • Dimerization
  • Indole Alkaloids / chemical synthesis*
  • Indole Alkaloids / chemistry
  • Molecular Structure
  • Sunlight*

Substances

  • Cyclobutanes
  • Indole Alkaloids
  • dictazole B