[Prostate-specific antigen (PA) and deoxyribonucleic acid (DNA) analysis in prostatic epithelial cells using flow cytometry]

Hinyokika Kiyo. 1989 Aug;35(8):1335-7.
[Article in Japanese]

Abstract

We developed a new method to analyze simultaneously cellular prostate-specific antigen (PA) content and deoxyribonucleic acid (DNA) content of each prostatic epithelial cell by using flow cytometry (FCM). We report the possibilities of this method and we analyzed firstly 8 samples from 6 patients with benign prostatic hypertrophy (BPH). The content of cellular PA and DNA of prostatic epithelial cells can be analyzed simultaneously. The PA is synthesized only in the cells with a 2C DNA content (G0/1 cells) and not in the S- or G2M-phase cells. In the near future, by applying this analytical method to prostatic cancer samples we could obtain more interesting knowledge of the behavior of prostatic cancer.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Antigens, Neoplasm
  • DNA / analysis*
  • Epithelial Cells
  • Flow Cytometry / methods
  • Humans
  • Male
  • Middle Aged
  • Prostate / cytology
  • Prostate / immunology*
  • Prostate-Specific Antigen
  • Prostatic Hyperplasia / pathology

Substances

  • Antigens, Neoplasm
  • DNA
  • Prostate-Specific Antigen