Suture choice matters in rabbit model of laparoscopic, preperitoneal, inguinal hernia repair

J Laparoendosc Adv Surg Tech A. 2014 Jun;24(6):428-31. doi: 10.1089/lap.2013.0352. Epub 2014 Apr 30.

Abstract

Purpose: We evaluated the effect of different suture materials in a laparoscopic preperitoneal ligation of the patent processus vaginalis in a rabbit survival model.

Materials and methods: New Zealand White rabbits underwent laparoscopic assisted preperitoneal ligation of the patent processus vaginalis. The processus vaginalis was closed with silk (n=10), polyglactin 910 (Vicryl(®); Ethicon, a Johnson & Johnson Company, Somerville, NJ) (n=10), or polypropylene (Prolene(®); Ethicon) (n=10). At necropsy, the suture was removed, and repair integrity was evaluated.

Results: All rabbits survived to necropsy without complications. No suture material was identified during necropsy of the Vicryl group. Eight (80%) of the Vicryl closures failed, with six (60%) failing at initial inspection. Following removal of suture material, nine (90%) of the Prolene closures failed, and only one (10%) of the silk closures failed (P=.009).

Conclusions: The silk suture resulted in an improved closure rate. Ligation with silk suture probably incited an increased inflammatory response that likely created a scar while persisting long enough for the scar to become established. In contrast, the Vicryl sutures probably failed because the sutures dissolved before a scar was able to fully develop. Finally, the Prolene closures were suture dependent as evidenced by failure when the suture was removed. Nonabsorbable braided suture may improve closure of pediatric indirect inguinal hernias during laparoscopic-assisted preperitoneal ligation.

MeSH terms

  • Animals
  • Cicatrix
  • Hernia, Inguinal / surgery*
  • Laparoscopy / methods*
  • Male
  • Peritoneum / surgery
  • Polyglactin 910 / adverse effects*
  • Polypropylenes / adverse effects*
  • Rabbits
  • Silk / adverse effects*
  • Sutures / adverse effects*
  • Testicular Hydrocele / surgery

Substances

  • Polypropylenes
  • Silk
  • Polyglactin 910