Vemurafenib-Induced Disseminated Intravascular Coagulation in Metastatic Melanoma

J Clin Oncol. 2015 Dec 20;33(36):e133-4. doi: 10.1200/JCO.2013.51.4471. Epub 2014 Apr 28.
No abstract available

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Biomarkers / blood
  • Biomarkers, Tumor / blood
  • Brain Neoplasms / complications
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / secondary
  • Databases, Factual
  • Disseminated Intravascular Coagulation / blood
  • Disseminated Intravascular Coagulation / chemically induced*
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / etiology
  • Drug Administration Schedule
  • Fatal Outcome
  • Fibrin Fibrinogen Degradation Products / drug effects
  • Fibrinogen / metabolism
  • Humans
  • Indoles / administration & dosage
  • Indoles / adverse effects*
  • L-Lactate Dehydrogenase / blood
  • Male
  • Melanoma / complications
  • Melanoma / drug therapy*
  • Melanoma / genetics
  • Melanoma / secondary
  • Middle Aged
  • Mutation*
  • Pharmacovigilance*
  • Platelet Count
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
  • Proto-Oncogene Proteins B-raf / genetics
  • Recurrence
  • S100 Calcium Binding Protein beta Subunit / blood
  • Skin Neoplasms / complications
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology
  • Sulfonamides / administration & dosage
  • Sulfonamides / adverse effects*
  • Tumor Burden / drug effects
  • Vemurafenib

Substances

  • Antineoplastic Agents
  • Biomarkers
  • Biomarkers, Tumor
  • Fibrin Fibrinogen Degradation Products
  • Indoles
  • S100 Calcium Binding Protein beta Subunit
  • Sulfonamides
  • fibrin fragment D
  • Vemurafenib
  • Fibrinogen
  • L-Lactate Dehydrogenase
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf