CSF T-cell subsets in multiple sclerosis: relationship to cerebrospinal fluid myelin basic protein and clinical activity

J Neurol. 1989 Sep;236(6):336-9. doi: 10.1007/BF00314375.

Abstract

Cerebrospinal fluid myelin basic protein and cerebrospinal fluid and peripheral blood T-cell subsets have been studied in patients with multiple sclerosis and other inflammatory and non-inflammatory nervous system diseases. These biological parameters have been correlated with clinical disease activity. No changes in peripheral blood T-cell subsets were seen in multiple sclerosis patients. Low cerebrospinal fluid T8+ cells occurred only in multiple sclerosis, while high cerebrospinal fluid T4+ cells were detected both in clinically active multiple sclerosis and in inflammatory nervous system diseases. A close relationship was found between cerebrospinal fluid T4/T8 ratio and myelin basic protein in relapsing multiple sclerosis patients.

MeSH terms

  • Adolescent
  • Adult
  • CD4-Positive T-Lymphocytes / immunology
  • Cerebrospinal Fluid / cytology
  • Child
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / immunology*
  • Myelin Basic Protein / cerebrospinal fluid*
  • Nervous System Diseases / cerebrospinal fluid
  • Nervous System Diseases / immunology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Regulatory / immunology

Substances

  • Myelin Basic Protein