A highly sensitive and reductant-resistant fluorescent probe for nitroxyl in aqueous solution and serum

Chem Commun (Camb). 2014 Jun 1;50(43):5790-2. doi: 10.1039/c4cc01440e. Epub 2014 Apr 23.

Abstract

A novel coumarin-based fluorescent probe, P-CM, for quantitative detection of nitroxyl (HNO) was developed. P-CM exhibits a selective response to HNO over other biological reductants and was also applied for quantitative detection of HNO in bovine serum with satisfactory results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Fluorescent Dyes / chemistry*
  • Nitrogen Oxides / blood*
  • Nitrogen Oxides / chemistry*
  • Reducing Agents / chemistry
  • Spectrometry, Fluorescence
  • Water / chemistry*

Substances

  • Fluorescent Dyes
  • Nitrogen Oxides
  • Reducing Agents
  • Water
  • nitroxyl