The association between TGF-β1 polymorphisms and radiation pneumonia in lung cancer patients treated with definitive radiotherapy: a meta-analysis

PLoS One. 2014 Mar 18;9(3):e91100. doi: 10.1371/journal.pone.0091100. eCollection 2014.

Abstract

Background: Previous studies investigating the association between TGF-β1 polymorphisms and Radiation Pneumonia (RP) risk have provided inconsistent results. The aim of our study was to assess the association between the TGF-β1 genes C509T, G915C and T869C polymorphisms and risk of RP in lung cancer patients treated with definitive radiotherapy.

Methods: Two investigators independently searched the Medline, Embase, CNKI, and Chinese Biomedicine Databases for studies published before September 2013. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for TGF-β1 polymorphisms and RP were calculated in a fixed-effects model or a random-effects model when appropriate.

Results: Ultimately, each 7 studies were found to be eligible for meta-analyses of C509T, G915C and T869C, respectively. Our analysis suggested that the variant genotypes of T869C were associated with a significantly increased RP risk in dominant model (OR = 0.59, 95% CI = 0.45-0.79) and CT vs. TT model (OR = 0.47, 95% CI = 0.32-0.69). In the subgroup analyses by ethnicity/country, a significantly increased risk was observed among Caucasians. For C509T and G915C polymorphism, no obvious associations were found for all genetic models.

Conclusion: This meta-analysis suggests that T869C polymorphism of TGF-β1 may be associated with RP risk only in Caucasians, and there may be no association between C509T and G915C polymorphism and RP risk.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People
  • Gamma Rays / adverse effects*
  • Gamma Rays / therapeutic use
  • Genetic Predisposition to Disease
  • Humans
  • Lung Neoplasms / ethnology
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Lung Neoplasms / radiotherapy*
  • Models, Genetic
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Radiation Pneumonitis / ethnology
  • Radiation Pneumonitis / etiology*
  • Radiation Pneumonitis / genetics
  • Radiation Pneumonitis / pathology
  • Risk
  • Transforming Growth Factor beta1 / genetics*
  • White People

Substances

  • Transforming Growth Factor beta1

Grants and funding

This work was supported by National Major Project of China (2011ZX09302-001-01) and National Natural Science Fund of China (81101698). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.