Pylorus-preserving versus pylorus-resecting pancreaticoduodenectomy for periampullary and pancreatic carcinoma: a meta-analysis

Chong Yang; He-Shui Wu; Xing-Lin Chen; Chun-You Wang; Shan-Miao Gou; Jun Xiao; Zhi-Qiang He; Qi-Jun Chen; Yong-Feng Li

doi:10.1371/journal.pone.0090316

Pylorus-preserving versus pylorus-resecting pancreaticoduodenectomy for periampullary and pancreatic carcinoma: a meta-analysis

PLoS One. 2014 Mar 6;9(3):e90316. doi: 10.1371/journal.pone.0090316. eCollection 2014.

Authors

Chong Yang¹, He-Shui Wu¹, Xing-Lin Chen², Chun-You Wang¹, Shan-Miao Gou¹, Jun Xiao¹, Zhi-Qiang He¹, Qi-Jun Chen¹, Yong-Feng Li¹

Affiliations

¹ Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
² Key Laboratory of Geriatrics of Health Ministry, Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Abstract

Background: The aim of this meta-analysis was to compare the long-term survival, mortality, morbidity and the operation-related events in patients with periampullary and pancreatic carcinoma undergoing pylorus-preserving pancreaticoduodenectomy (PPPD) and pylorus-resecting pancreaticoduodenectomy (PRPD).

Method: A systematic search of literature databases (Cochrane Library, PubMed, EMBASE and Web of Science) was performed to identify studies. Outcome measures comparing PPPD versus PRPD for periampullary and pancreatic carcinoma were long-term survival, mortality, morbidity (overall morbidity, delayed gastric emptying [DGE], pancreatic fistula, wound infection, postoperative bleeding, biliary leakage, ascites and gastroenterostomy leakage) and operation related events (hospital stays, operating time, intraoperative blood loss and red blood cell transfusions).

Results: Eight randomized controlled trials (RCTs) including 622 patients were identified and included in the analysis. Among these patients, it revealed no difference in long-term survival between the PPPD and PRPD groups (HR = 0.23, p = 0.11). There was a lower rate of DGE (RR = 2.35, p = 0.04, 95% CI, 1.06-5.21) with PRPD. Mortality, overall morbidity, pancreatic fistula, wound infection, postoperative bleeding, biliary leakage, ascites and gastroenterostomy leakage were not significantly different between the groups. PPPDs were performed more quickly than PRPDs (WMD = 53.25 minutes, p = 0.01, 95% CI, 12.53-93.97); and there was less estimated intraoperative blood loss (WMD = 365.21 ml, p = 0.006, 95% CI, 102.71-627.71) and fewer red blood cell transfusions (WMD = 0.29 U, p = 0.003, 95% CI, 0.10-0.48) in patients undergoing PPPD. The hospital stays showed no significant difference.

Conclusions: PPPD had advantages over PRPD in operating time, intraoperative blood loss and red blood cell transfusions, but had a significantly higher rate of DGE for periampullary and pancreatic carcinoma. PPPD and PRPD had comparable mortality and morbidity including pancreatic fistulas, wound infections, postoperative bleeding, biliary leakage, ascites and gastroenterostomy leakage. Our conclusions were limited by the available data. Further evaluations of high-quality RCTs are needed.

Publication types

Comparative Study
Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Ampulla of Vater / surgery*
Common Bile Duct Neoplasms / surgery*
Hemorrhage / etiology
Humans
Intraoperative Complications / etiology
Pancreatic Neoplasms / surgery*
Pancreaticoduodenectomy / adverse effects
Pancreaticoduodenectomy / methods*
Pylorus / surgery*
Randomized Controlled Trials as Topic
Survival Analysis
Time Factors
Treatment Outcome

Grants and funding

This study is supported by the National Natural Science Foundation of China(No 81372261). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.