SIRT1 metabolic actions: Integrating recent advances from mouse models

Marie Boutant; Carles Cantó

doi:10.1016/j.molmet.2013.10.006

SIRT1 metabolic actions: Integrating recent advances from mouse models

Mol Metab. 2013 Oct 23;3(1):5-18. doi: 10.1016/j.molmet.2013.10.006. eCollection 2014 Feb.

Authors

Marie Boutant¹, Carles Cantó¹

Affiliation

¹ Nestlé Institute of Health Sciences S.A., EPFL campus, Quartier de l'Innovation, Bâtiment G, CH-1015 Lausanne, Switzerland.

Abstract

SIRT1 has attracted a lot of interest since it was discovered as a mammalian homolog of Sir2, a protein that influences longevity in yeast. Intensive early research suggested a key role of SIRT1 in mammalian development, metabolic flexibility and oxidative metabolism. However, it is the growing body of transgenic models that are allowing us to clearly define the true range of SIRT1 actions. In this review we aim to summarize the most recent lessons that transgenic animal models have taught us about the role of SIRT1 in mammalian metabolic homeostasis and lifespan.

Keywords: Energy homeostasis; Insulin resistance; SIRT1; Transgenic models.

Publication types

Review