Detection and complete genome characterization of human enterovirus 118 from children with acute respiratory disease in China

Virus Genes. 2014 Jun;48(3):534-7. doi: 10.1007/s11262-014-1044-1. Epub 2014 Feb 22.

Abstract

Enterovirus 118 (EV-118) within species HEV-C was detected in two 5-month-old boys with pneumonia in China. The EV-118 from both cases was genetically closer to ISR10 strain from Israel than to PER161 strain from Peru based on VP1 gene sequences. The complete genome of the detected EV-118 consists of 7,360 nucleotides, excluding the poly (A) tail. The 5'UTR contains 669 nucleotides, and 3'UTR consists of 73 nucleotides. A single open reading frame from base 670 to 7,287 that encodes a 2,206-amino-acid polyprotein was featured. The base composition of the full genome is 27.9 % A, 24.2 % C, 24.4 % G, and 23.6 % U. Phylogenetic analysis of the full genome sequences illustrated EV-118 was genetically closer to EV-109 and EV-105, and the Chinese strain differed from Peru strain. In summary, the presence of EV-118 was confirmed in pediatric pneumonia cases and complete genome sequences were identified for the first time in China.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Base Sequence
  • China
  • Enterovirus / classification
  • Enterovirus / genetics*
  • Enterovirus / isolation & purification*
  • Enterovirus Infections / virology*
  • Genome, Viral*
  • Humans
  • Infant
  • Male
  • Molecular Sequence Data
  • Open Reading Frames
  • Phylogeny
  • Respiratory Tract Diseases / virology*
  • Viral Proteins / genetics

Substances

  • Viral Proteins