Relationships between DNA and protein polymorphisms of apolipoprotein B

Hum Genet. 1988 Apr;78(4):325-9. doi: 10.1007/BF00291728.

Abstract

The associations between four restriction fragment length polymorphisms (RFLPs) of the gene for human apolipoprotein B (apo B) and five antigen group (Ag) protein-polymorphisms of apo B have been investigated in 24 unrelated Finnish individuals. In this sample a complete correlation exists between the EcoRI RFLP and the Ag(t/z) polymorphism. There is strong association between the alleles of the XbaI RFLP and Ag(c/g) and a weaker one of the same XbaI site with Ag(x/y). Linkage disequilibrium is observed between the PvuII RFLP and the Ag(a1/d) polymorphism. These associations confirm that the Ag variants are true protein sequence polymorphisms of apo B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoproteins B / genetics*
  • Apolipoproteins B / immunology
  • DNA / analysis
  • DNA Restriction Enzymes
  • Deoxyribonuclease EcoRI
  • Epitopes / genetics
  • Genetic Linkage
  • Genetic Markers
  • Humans
  • Phenotype
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length*

Substances

  • Apolipoproteins B
  • Epitopes
  • Genetic Markers
  • DNA
  • DNA Restriction Enzymes
  • Deoxyribonuclease EcoRI