Health-related quality of life in small-cell lung cancer: a systematic review on reporting of methods and clinical issues in randomised controlled trials

Efstathios Zikos; Irina Ghislain; Corneel Coens; Divine E Ediebah; Elizabeth Sloan; Chantal Quinten; Michael Koller; Jan P van Meerbeeck; Hans-Henning Flechtner; Roger Stupp; Athanasios Pallis; Agnes Czimbalmos; Mirjam A G Sprangers; Andrew Bottomley

doi:10.1016/S1470-2045(13)70493-5

Health-related quality of life in small-cell lung cancer: a systematic review on reporting of methods and clinical issues in randomised controlled trials

Lancet Oncol. 2014 Feb;15(2):e78-89. doi: 10.1016/S1470-2045(13)70493-5.

Affiliations

¹ Quality of Life Department, EORTC Headquarters, Brussels, Belgium. Electronic address: efstathios.zikos@eortc.be.
² Quality of Life Department, EORTC Headquarters, Brussels, Belgium.
³ New England Center for Children, Southborough, Massachusetts, MA, USA.
⁴ European Centre for Disease Prevention and Control, Surveillance and Response Support Unit, Stockholm, Sweden.
⁵ University Hospital Regensburg, Center for Clinical Studies, Regensburg, Germany.
⁶ Multidisciplinary Oncology Centre Antwerp (MOCA)/Thoracic Oncology, Antwerp University Hospital, Edegem, Belgium.
⁷ University of Magdeburg, Child and Adolescent Psychiatry and Psychotherapy, Magdeburg, Germany.
⁸ Department of Oncology and Cancer Center, University Hospital Zurich, Zurich, Switzerland.
⁹ Clinical Research Physicians Unit, EORTC Headquarters, Brussels, Belgium.
¹⁰ Hungaroprax NC, Budapest, Hungary.
¹¹ Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

PMID: 24480558
DOI: 10.1016/S1470-2045(13)70493-5

Abstract

Small-cell lung cancer represents about 15% of all lung cancers; increasingly, randomised controlled trials of this disease measure the health-related quality of life of patients. In this Systematic Review we assess the adequacy of reporting of health-related quality-of-life methods in randomised controlled trials of small-cell lung cancer, and the potential effect of this reporting on clinical decision making. Although overall reporting of health-related quality of life was acceptable, improvements are needed to optimise the use of health-related quality of life in randomised controlled trials.

Publication types

Review
Systematic Review

MeSH terms

Activities of Daily Living
Adaptation, Psychological
Cost of Illness
Evidence-Based Medicine
Humans
Lung Neoplasms / diagnosis
Lung Neoplasms / psychology*
Lung Neoplasms / therapy
Prognosis
Quality of Life*
Randomized Controlled Trials as Topic / methods*
Research Design*
Small Cell Lung Carcinoma / diagnosis
Small Cell Lung Carcinoma / psychology*
Small Cell Lung Carcinoma / therapy
Surveys and Questionnaires