A biological response modifier, PSK, inhibits reverse transcriptase in vitro

K Hirose; M Hakozaki; J Kakuchi; K Matsunaga; C Yoshikumi; M Takahashi; T S Tochikura; N Yamamoto

doi:10.1016/0006-291x(87)90404-9

A biological response modifier, PSK, inhibits reverse transcriptase in vitro

Biochem Biophys Res Commun. 1987 Dec 16;149(2):562-7. doi: 10.1016/0006-291x(87)90404-9.

Authors

K Hirose¹, M Hakozaki, J Kakuchi, K Matsunaga, C Yoshikumi, M Takahashi, T S Tochikura, N Yamamoto

Affiliation

¹ Biomedical Research Laboratory, Kureha Chemical Industry Co., Ltd., Tokyo, Japan.

PMID: 2447880
DOI: 10.1016/0006-291x(87)90404-9

Abstract

We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important in its anti-HIV effect as well as its inhibitory effect on the binding of HIV with lymphocytes.

MeSH terms

Acquired Immunodeficiency Syndrome / drug therapy
Dose-Response Relationship, Drug
HIV / drug effects
Humans
Kinetics
Proteoglycans / pharmacology*
Proteoglycans / therapeutic use
Reverse Transcriptase Inhibitors*

Substances

Proteoglycans
Reverse Transcriptase Inhibitors
polysaccharide-K