Enzyme-controllable F-NMR turn on through disassembly of peptide-based nanospheres for enzyme detection

Org Biomol Chem. 2014 Mar 7;12(9):1383-6. doi: 10.1039/c3ob42078g.

Abstract

The enzyme tyrosinase could trigger the disassembly of peptide-based nanospheres, resulting in F-NMR signal turning on.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Fluorine / chemistry
  • Fluorine / metabolism
  • Mice
  • Molecular Conformation
  • Monophenol Monooxygenase / analysis*
  • Monophenol Monooxygenase / metabolism*
  • NIH 3T3 Cells
  • Nanospheres / chemistry*
  • Nanospheres / metabolism
  • Nuclear Magnetic Resonance, Biomolecular*
  • Peptides / chemistry*
  • Peptides / metabolism
  • Peptides / pharmacology
  • Structure-Activity Relationship

Substances

  • Peptides
  • Fluorine
  • Monophenol Monooxygenase