Spousal loss and cognitive function in later life: a 25-year follow-up in the AGES-Reykjavik study

Am J Epidemiol. 2014 Mar 15;179(6):674-83. doi: 10.1093/aje/kwt321. Epub 2014 Jan 19.

Abstract

The aim of this study was to investigate the associations between loss of a life partner and the development of dementia and decline in cognitive function in later life. We used an Icelandic cohort of 4,370 participants in the Age, Gene/Environment Susceptibility-Reykjavik Study who were living as married in 1978 (born in 1907-1935) and were either still married (unexposed cohort) or widowed (exposed cohort) at follow-up (in 2002-2006). We ascertained history of marital status and spouse's death by record linkage to the Registry of the Total Population, Statistics Iceland. The outcome measures were as follows: 1) dementia and mild cognitive impairment; and 2) memory, speed of processing, and executive function. During the observation period, 3,007 individuals remained married and 1,363 lost a spouse through death. We did not find any significant associations between loss of a spouse and our outcome variables, except that widowed women had poorer executive function (mean = -0.08) during the first 2 years after their husbands' deaths compared with still-married women (mean = 0.09). Our findings do not support the notion that the risk of dementia is increased following the loss of a spouse, yet women demonstrate a seemingly temporary decline in executive function following the death of a partner.

Keywords: dementia; executive function; marital status; memory; psychological stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Apolipoproteins E / genetics
  • Cognition*
  • Cognitive Dysfunction / epidemiology*
  • Cognitive Dysfunction / psychology
  • Dementia / epidemiology*
  • Dementia / psychology
  • Executive Function
  • Female
  • Humans
  • Iceland / epidemiology
  • Male
  • Memory
  • Sex Factors
  • Socioeconomic Factors
  • Stress, Psychological / epidemiology
  • Stress, Psychological / psychology
  • Time Factors
  • Widowhood / psychology
  • Widowhood / statistics & numerical data*

Substances

  • Apolipoproteins E