Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

Nature. 1987 Jul;328(6125):38-43. doi: 10.1038/328038a0.

Abstract

Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aplysia / physiology*
  • Arachidonic Acid
  • Arachidonic Acids / metabolism*
  • Arachidonic Acids / pharmacology
  • Electrophysiology
  • FMRFamide
  • Hydroxy Acids / metabolism
  • Hydroxyeicosatetraenoic Acids / physiology
  • Ion Channels / drug effects
  • Ion Channels / physiology
  • Leukotrienes*
  • Lipoxygenase / metabolism*
  • Neurons, Afferent / drug effects
  • Neurons, Afferent / physiology*
  • Neuropeptides / pharmacology
  • Phospholipases / antagonists & inhibitors
  • Synapses / physiology*

Substances

  • Arachidonic Acids
  • Hydroxy Acids
  • Hydroxyeicosatetraenoic Acids
  • Ion Channels
  • Leukotrienes
  • Neuropeptides
  • Arachidonic Acid
  • FMRFamide
  • 12-HPETE
  • Lipoxygenase
  • Phospholipases