Recurrent wheeze is a very frequent disease during infancy. In many cases, this condition is a transient one, but some infants who suffer from this illness, have a persistent recurrent wheeze. During the past decades different international cohorts have been designed to answer what are the risk factors to develop recurrent wheeze and to make the conditon persistent even into the adulthood. Infant lung function could explain some aspects of this pathophysiology. The aim of this article is to review the current knowledge on the relationships of recurrent wheeze with an eventual impairment in lung function, the beginning of this impairment early in life, its relationship with asthma later in life and what risk factors are related with low lung function.