Toward effective probiotics for autism and other neurodevelopmental disorders

Jack A Gilbert; Rosa Krajmalnik-Brown; Dorota L Porazinska; Sophie J Weiss; Rob Knight

doi:10.1016/j.cell.2013.11.035

Toward effective probiotics for autism and other neurodevelopmental disorders

Cell. 2013 Dec 19;155(7):1446-8. doi: 10.1016/j.cell.2013.11.035.

Authors

Jack A Gilbert¹, Rosa Krajmalnik-Brown², Dorota L Porazinska³, Sophie J Weiss³, Rob Knight⁴

Affiliations

¹ Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA; Department of Ecology and Evolution, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA.
² Swette Center for Environmental Biotechnology Biodesign Institute at Arizona State University, 1001 South McAllister Avenue, Tempe, AZ 85287-5701, USA; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85287-5701, USA.
³ Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA.
⁴ Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Boulder, CO 80309, USA. Electronic address: rob.knight@colorado.edu.

Abstract

Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Child Development Disorders, Pervasive / microbiology*
Female
Gastrointestinal Tract / microbiology*
Humans

Abstract

Publication types

MeSH terms

Grants and funding