Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer

Abstract

Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450 epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to regulate various biological processes including inflammation, pain and angiogenesis. The EpFAs are further metabolized by soluble epoxide hydrolase (sEH) to form fatty acid diols which are usually less-active. Pharmacological inhibitors of sEH that stabilize endogenous EpFAs are being considered for human clinical uses. Here we review the biology of ω-3 and ω-6 EpFAs on inflammation, pain, angiogenesis and tumorigenesis.

Keywords: Cytochrome P450 epoxygenase; Epoxydocosapentaenoic acids; Epoxyeicosatrienoic acids; Soluble epoxide hydrolase.