Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach

Annie Yarwood; Sebastien Viatte; Darren Plant; Ann W Morgan; John Isaacs; Anthony G Wilson; Kimme Hyrich; Steve Eyre; Anne Barton; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS)

doi:10.1136/annrheumdis-2013-204443

Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach

Ann Rheum Dis. 2014 May;73(5):938-40. doi: 10.1136/annrheumdis-2013-204443. Epub 2013 Dec 9.

Authors

Annie Yarwood¹, Sebastien Viatte, Darren Plant, Ann W Morgan, John Isaacs, Anthony G Wilson, Kimme Hyrich, Steve Eyre, Anne Barton; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS)

Collaborators

Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS):
H Gaston, D Mulherin, T Price, T Sheeran, V Chalam, S Baskar, P Emery, A W Morgan, M Buch, S Bingham, S O'Reilly, L Badcock, M Regan, T Ding, C Deighton, G Summers, N Raj, R Stevens, N Williams, J Isaacs, P Platt, D Walker, L Kay, B Griffiths, W-F Ng, P Peterson, A Lorenzi, H Foster, M Friswell, B Thompson, M Lee, I Griffiths, A Hassell, P Dawes, C Dowson, S Kamath, J Packham, M Shadforth, R Williams, C Mukhtyar, B Harrison, N Snowden, S Naz, J Ledingham, R Hull, F McCrae, A Thomas, S Young Min, R Shaban, E Wong, C Kelly, C Heycock, J Hamilton, V Saravanan, G Wilson, D Bax, L Dunkley, M Akil, R Tattersall, R Kilding, S Till, J Boulton, T Tait, M Bukhari, J Halsey, L Ottewell, C Buckley, D Situnayake, D Carruthers, K Grindulis, F Khatack, S Elamanchi, K Raza, A Filer, R Jubb, R Abernathy, M Plant, S Pathare, F Clarke, S Tuck, J Fordham, A Paul, M Bridges, A Hakim, D O'Reilly, V Rajagopal, S Bhagat, C Edwards, P Prouse, R Moitra, D Shawe, A Bamji, P Klimiuk, A Bowden, W Mitchell, I Bruce, A Barton, R Gorodkin, P Ho, K Hyrich, W Dixon, A Rai, G Kitas, N Erb, R Klocke, K Douglas, A Pace, R Sandhu, A Whallett, F Birrell, M Allen, K Chaudhuri, C Chattopadhyay, J McHale, A Jones, A Gupta, I Pande, I Gaywood, P Lanyon, P Courtney, M Doherty, H Chinoy, T O'Neill, A Herrick, A Jones, R Cooper, R Bucknall, C Marguerie, S Rigby, N Dunn, S Green, A Al-Ansari, S Webber, N Hopkinson, C Dunne, B Quilty, B Szebenyi, M Green, M Quinn, A Isdale, A Brown, B Saleem, A Samanta, P Sheldon, W Hassan, J Francis, A Kinder, R Neame, A Moorthy, W Al-Allaf, A Taggart, K Fairburn, F McKenna, M Green, A Gough, C Lawson, M Piper, E Korendowych, T Jenkinson, R Sengupta, A Bhalla, N McHugh, Debbie Bond, R Luqmani, B Bowness, P Wordsworth, J David, W Smith, D Mewar, E Tunn, K Nelson, T Kennedy, J Nixon, A Woolf, M Davis, D Hutchinson, A Endean, D Coady, D Wright, C Morley, G Raftery, C Bracewell, L Kidd, I Abbas, C Filer, G Kallarackal

Affiliation

¹ Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, , Manchester, UK.

PMID: 24323394
DOI: 10.1136/annrheumdis-2013-204443

No abstract available

Keywords: Anti-TNF; Autoimmune Diseases; Gene Polymorphism; Rheumatoid Arthritis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / genetics*
Drug Resistance / genetics*
Genetic Predisposition to Disease / genetics*
Humans
Polymorphism, Single Nucleotide
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Vitamin D / metabolism*

Substances

Antirheumatic Agents
Tumor Necrosis Factor-alpha
Vitamin D

Publication types

MeSH terms

Substances

Grants and funding