Pediatric thrombophilia

Abstract

Pediatric thrombosis and thrombophilia are increasingly recognized and studied. In this article, both the inherited and acquired factors for the development of thrombosis in neonates and children are categorized using the elements of Virchow's triad: stasis, hypercoagulable state, and vascular injury. The indications and rationale for performing thrombophilia testing are described. Also included are discussions on who, how, when, and why to test. Finally, recommendations for the use of contraceptives for adolescent females with a family history of thrombosis are outlined.

Keywords: Arterial ischemic stroke; Cerebral sinus venous thrombosis; Pediatric thrombosis; Thrombophilia; Venous thromboembolic event.