Pseudo-peptides as novel antileptospiral agents: synthesis and spectral characterization

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24:118:1152-7. doi: 10.1016/j.saa.2013.09.105. Epub 2013 Oct 8.

Abstract

In this paper, we describe the synthesis of novel class of pseudo-peptides derived by coupling an amino acid with a heterocyclic moiety containing free amine group using suitable coupling agents. The synthesized compounds were characterized using spectral ((1)H NMR, (13)C NMR and MS) techniques. Preliminary pharmacological assays for Leptospirosis were studied by test tube dilution (TDT) and micro dilution technique (MDT). In particular, all the analyses led to the conclusion that the synthesized compound inhibiting the Leptospira a causal organism of Leptospirosis.

Keywords: Anti-leptospiral activity; Minimum inhibitory concentration; Pseudo-peptide; Spectroscopic technique.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Humans
  • Leptospira / drug effects*
  • Leptospirosis / drug therapy
  • Models, Molecular
  • Peptidomimetics / chemical synthesis
  • Peptidomimetics / chemistry*
  • Peptidomimetics / pharmacology*
  • Tryptophan / analogs & derivatives
  • Tryptophan / chemical synthesis
  • Tryptophan / pharmacology

Substances

  • Anti-Bacterial Agents
  • Peptidomimetics
  • Tryptophan