B-Raf mutation: a key player in molecular biology of cancer

M A Rahman; A Salajegheh; R A Smith; A K-Y Lam

doi:10.1016/j.yexmp.2013.10.005

B-Raf mutation: a key player in molecular biology of cancer

Exp Mol Pathol. 2013 Dec;95(3):336-42. doi: 10.1016/j.yexmp.2013.10.005. Epub 2013 Oct 23.

Authors

M A Rahman¹, A Salajegheh, R A Smith, A K-Y Lam

Affiliation

¹ Cancer Molecular Pathology Group, Griffith Health Institute, Griffith University, Gold Coast, Australia.

PMID: 24161954
DOI: 10.1016/j.yexmp.2013.10.005

Abstract

B-Raf is one of the more commonly mutated proto-oncogenes implicated in the development of cancers. In this review, we consider the mechanisms and clinical impacts of B-Raf mutations in cancer and discuss the implications for the patient in melanoma, thyroid cancer and colorectal cancer, where B-Raf mutations are particularly common.

Keywords: B-Raf; BRAF; Colorectal cancer; Melanoma; Mutation; Thyroid cancer.

Publication types

Review

MeSH terms

Humans
Mutation / genetics*
Neoplasms / genetics*
Neoplasms / pathology
Proto-Oncogene Proteins B-raf / genetics*

Substances

BRAF protein, human
Proto-Oncogene Proteins B-raf