Over the past two decades, industrial activity has increased rapidly in developing nations. Industrial growth has also increased the health risks facing workers in these countries both by intensifying existing health problems and by introducing new hazards. Inadequate information about occupational hazards creates major obstacles to effective prevention of occupational diseases in many developing countries. This brief report reviews the occupational health determinants of developing nations and suggests current research needs and objectives. Our purpose is to stimulate discussion and initiate debate among health professionals worldwide who confront growing problems in occupational health.