Abstract
Comprehensive virome analysis of RNA sequence (RNA-seq) data sets from 118 non-Hodgkin's B-cell lymphomas revealed a small subset that is positive for Epstein-Barr virus (EBV) or human herpesvirus 6B (HHV-6B), with one coinfection. EBV transcriptome analysis revealed expression of the latency genes RPMS1, LMP1, and LMP2, with one sample additionally showing a high level of early lytic expression and another sample showing a high level of EBNA2 expression. HHV-6B transcriptome analysis revealed that the majority of genes were transcribed.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Cohort Studies
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Epstein-Barr Virus Infections / diagnosis
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Epstein-Barr Virus Infections / virology*
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Gene Expression Regulation, Viral
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / isolation & purification*
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Herpesvirus 6, Human / genetics
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Herpesvirus 6, Human / isolation & purification*
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Humans
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Lymphoma, Large B-Cell, Diffuse / diagnosis
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Lymphoma, Large B-Cell, Diffuse / virology*
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Roseolovirus Infections / diagnosis
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Roseolovirus Infections / virology*
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Sequence Analysis, RNA
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Viral Proteins / genetics*