WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury

J Neurosci. 2013 Sep 11;33(37):14778-90. doi: 10.1523/JNEUROSCI.1331-13.2013.

Abstract

Mitochondria carry out many of the processes implicated in maintaining axon health or causing axon degeneration, including ATP and reactive oxygen species (ROS) generation, as well as calcium buffering and protease activation. Defects in mitochondrial function and transport are common in axon degeneration, but how changes in specific mitochondrial properties relate to degeneration is not well understood. Using cutaneous sensory neurons of living larval zebrafish as a model, we examined the role of mitochondria in axon degeneration by monitoring mitochondrial morphology, transport, and redox state before and after laser axotomy. Mitochondrial transport terminated locally after injury in wild-type axons, an effect that was moderately attenuated by expressing the axon-protective fusion protein Wallerian degeneration slow (WldS). However, mitochondrial transport arrest eventually occurred in WldS-protected axons, indicating that later in the lag phase, mitochondrial transport is not required for axon protection. By contrast, the redox-sensitive biosensor roGFP2 was rapidly oxidized in the mitochondrial matrix after injury, and WldS expression prevented this effect, suggesting that stabilization of ROS production may mediate axon protection. Overexpression of PGC-1α, a transcriptional coactivator with roles in both mitochondrial biogenesis and ROS detoxification, dramatically increased mitochondrial density, attenuated roGFP2 oxidation, and delayed Wallerian degeneration. Collectively, these results indicate that mitochondrial oxidation state is a more reliable indicator of axon vulnerability to degeneration than mitochondrial motility.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Axons / pathology
  • Axons / physiology*
  • Axons / ultrastructure*
  • Axotomy / adverse effects
  • Disease Models, Animal
  • Female
  • LIM-Homeodomain Proteins / genetics
  • Larva
  • Luminescent Proteins / genetics
  • Luminescent Proteins / metabolism
  • Male
  • Membrane Potential, Mitochondrial / genetics
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Mitochondrial Proteins / genetics
  • Mitochondrial Proteins / metabolism
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Oxidation-Reduction
  • Reactive Oxygen Species / metabolism
  • Sensory Receptor Cells / cytology*
  • Sensory Receptor Cells / pathology
  • Sensory Receptor Cells / ultrastructure
  • Skin / cytology
  • Synaptophysin / genetics
  • Synaptophysin / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Zebrafish
  • Zebrafish Proteins / genetics
  • Zebrafish Proteins / metabolism*

Substances

  • LIM-Homeodomain Proteins
  • Luminescent Proteins
  • Mitochondrial Proteins
  • Nerve Tissue Proteins
  • Reactive Oxygen Species
  • Synaptophysin
  • Transcription Factors
  • Zebrafish Proteins
  • fluorescent protein 583
  • insulin gene enhancer binding protein Isl-1
  • peroxisome proliferator activated receptor gamma coactivator-1alpha, zebrafish