ent-Labdane diterpenes from the stems of Mallotus japonicus

J Nat Prod. 2013 Sep 27;76(9):1580-5. doi: 10.1021/np400241p. Epub 2013 Aug 30.

Abstract

Eight new ent-labdane diterpenoids, mallonicusins A-H (1-8), were isolated from the stems of Mallotus japonicus. Their structures, including the absolute configurations, were determined by extensive analyses of spectroscopic data and the ECD spectra of the Pr(FOD)₃ complex of substrates in CCl₄. The absolute configuration of compound 1 was confirmed by single-crystal X-ray crystallography using Cu Kα radiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Mallotus Plant / chemistry*
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Leaves / chemistry
  • Plant Stems / chemistry

Substances

  • Diterpenes
  • Drugs, Chinese Herbal