4C-ing the Igh Landscape

Laura Nicolás; Jayanta Chaudhuri

doi:10.1016/j.immuni.2013.08.014

4C-ing the Igh Landscape

Immunity. 2013 Aug 22;39(2):199-201. doi: 10.1016/j.immuni.2013.08.014.

Authors

Laura Nicolás¹, Jayanta Chaudhuri

Affiliation

¹ Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Abstract

The assembly of antigen receptors in developing B lymphocytes is determined by the spatio-temporal organization of the immunoglobulin heavy chain locus (Igh). In this issue of Immunity, Medvedovic et al. (2013) provide a comprehensive dynamic view of the Igh locus architecture.

Publication types

Comment

MeSH terms

Animals
Antibody Diversity / genetics*
Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics*
Genes, Immunoglobulin Heavy Chain*
Immunoglobulin Variable Region / genetics*
Precursor Cells, B-Lymphoid / immunology*

Substances

Immunoglobulin Variable Region

Grants and funding

R01 AI072194/AI/NIAID NIH HHS/United States