Nitroethylation of vinyl triflates and bromides

Org Lett. 2013 Aug 2;15(15):3966-9. doi: 10.1021/ol401747u. Epub 2013 Jul 25.

Abstract

A two-carbon homologation of vinyl triflates and bromides for the synthesis of homoallylic nitro products is described. This palladium-catalyzed double coupling of nitromethane exploits the anion stabilizing and leaving group properties of nitromethane, generating the homo allyl nitro products via a tandem cross-coupling/π-allylation sequence. The resultant process provides a mild and convenient entry to nitroethylated products, which are versatile precursors to β,γ-unsaturated carbonyls, homoallylic amines, and nitrile oxides.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkylation
  • Bromides / chemistry*
  • Catalysis
  • Mesylates / chemistry*
  • Nitro Compounds / chemical synthesis*
  • Nitro Compounds / chemistry
  • Palladium
  • Vinyl Compounds / chemistry*

Substances

  • Bromides
  • Mesylates
  • Nitro Compounds
  • Vinyl Compounds
  • vinyl triflate
  • Palladium