Exploring the genetic basis of stroke. Spanish stroke genetics consortium
Neurologia. 2014 Nov-Dec;29(9):560-6.
doi: 10.1016/j.nrl.2013.04.005.
Epub 2013 Jul 5.
[Article in
English,
Spanish]
Authors
E Giralt-Steinhauer
1
, J Jiménez-Conde
2
, C Soriano Tárraga
2
, M Mola
2
, A Rodríguez-Campello
2
, E Cuadrado-Godia
2
, A Ois
2
, I Fernández-Cádenas
3
, C Carrera
3
, J Montaner
3
, R M Díaz Navarro
4
, C Vives-Bauzá
4
, J Roquer
2
Affiliations
- 1 Grupo de Investigación Neurovascular, Departamento de Neurología, IMIM-Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: 96714@parcdesalutmar.cat.
- 2 Grupo de Investigación Neurovascular, Departamento de Neurología, IMIM-Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, España.
- 3 Laboratorio de Investigación Neurovascular, Institut de Recerca, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
- 4 Departamento de Neurología, Hospital Universitari Son Espases, Mallorca, Baleares, España.
Abstract
This article provides an overview of stroke genetics studies ranging from the candidate gene approach to more recent studies by the genome wide association. It highlights the complexity of stroke owing to its different aetiopathogenic mechanisms, the difficulties in studying its genetic component, and the solutions provided to date. The study emphasises the importance of cooperation between the different centres, whether this takes places occasionally or through the creation of lasting consortiums. This strategy is currently essential to the completion of high-quality scientific studies that allow researchers to gain a better knowledge of the genetic component of stroke as it relates to aetiology, treatment, and prevention.
Keywords:
Asociación; Association; Consorcio; Consortium; Factores de riesgo genético; Genetic risk factors; Genetics; Genética; Ictus; Predicción; Prediction; Stroke.
Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.
MeSH terms
-
Epigenesis, Genetic
-
Genetic Predisposition to Disease*
-
Genome-Wide Association Study
-
Humans
-
Polymorphism, Single Nucleotide
-
Risk Factors
-
Stroke / genetics*