Responsiveness to leukotriene D4 and methacholine for predicting efficacy of montelukast in asthma

Wei-Jie Guan; Jin-Ping Zheng; Yi Gao; Cai-Yu Jiang; Yan-Qing Xie; Xu Shi; Zheng Zhu; Jia-Ying An; Xin-Xin Yu; Wen-Ting Liu; Nan-Shan Zhong

doi:10.3978/j.issn.2072-1439.2013.02.01

Responsiveness to leukotriene D4 and methacholine for predicting efficacy of montelukast in asthma

J Thorac Dis. 2013 Jun;5(3):298-301. doi: 10.3978/j.issn.2072-1439.2013.02.01.

Authors

Wei-Jie Guan¹, Jin-Ping Zheng, Yi Gao, Cai-Yu Jiang, Yan-Qing Xie, Xu Shi, Zheng Zhu, Jia-Ying An, Xin-Xin Yu, Wen-Ting Liu, Nan-Shan Zhong

Affiliation

¹ State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China;

PMID: 23825762
PMCID: PMC3698267
DOI: 10.3978/j.issn.2072-1439.2013.02.01

Abstract

A lower responsiveness to leukotriene D4 (LTD4) or higher LTD4/[methacholine (MCh)] potency ratio might suggest preferable outcomes of short-term montelukast monotherapy in terms of airway inflammation and lung function in asthmatic patients.

Keywords: Asthma; leukotriene D4 (LTD4); leukotriene-responsive; leukotriene-unresponsive; methacholine (MCh); montelukast.

Abstract

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